Editorial: Metabolism and Immune Tolerance

Editorial: HLA-G-Mediated Immune Tolerance: Past and New Outlooks

This research topic gathered several researchers who actively base their research and investigations on the non-classical HLA-G molecule. HLA-G differs from classical HLA class I molecules since it has limited protein variability, can be expressed in several membrane-bound and soluble isoforms generated by alternative splicing generating, and modulates immune response. HLA-G expression is physi...

Editorial: Circadian Rhythms and Metabolism

Editorial: Drug Metabolism and Toxicology

A drug metabolism study is an important aspect of the early drug discovery and development process [1,2]. In order to improve the understanding of drug efficacy and safety characteristics, it is desirable to investigate the drug metabolism in animals or humans [3,4]. These metabolism studies involve metabolic stability, cytochrome P-450 (CYP-450) induction or inhibition and metabolite identific...

Editorial: Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology

This research topic was inspired in those still non-curable inflammatory conditions, such as autoim-mune diseases and transplant rejection, based on the fact that immunologists worldwide are still searching for strategies to restore long-term immune tolerance. Thus, we gathered several researchers whom actively base their investigation lines in novel molecules and immune cell populations that c...

Editorial: Control of Adipocyte Differentiation and Metabolism

For many years, adipose tissue was considered a passive tissue with the only function of storing excess energy as triglycerides and releasing fatty acids according to necessity. Now it becomes increasingly clear that adipose tissue is an endocrine organ that plays a critical role in modulating energy expenditure and homeostasis. White adipose tissue is thus responsible for the secretion of an a...